Beck WHJ., Kim D., Das J., Yu H., Smolka MB., Mao Y. Glucosylation by the Legionella Effector SetA Promotes Nuclear Localization of the Transcription Factor TFEB. iScience. 2020. 23(7) doi: 10.1016/j.isci.2020.101300.
Shin J-H., Sulpizio AG., Kelley A., Alvarez L., Murphy SG., Fan L., Cava F., Mao Y., Saper MA., Doerr T. Structural basis of peptidoglycan endopeptidase regulation. PNAS. 2020. 117(21):11692-11702 doi: 10.1073/pnas.2001661117.
Li C, Meng D, Piñeros MA, Mao Y, Dandekar AM, Cheng L. A Sugar Transporter Takes Up both Hexose and Sucrose for Sorbitol-Modulated In Vitro Pollen Tube Growth in Apple. Plant Cell. 2020 Feb;32(2):449-469. doi: 10.1105/tpc.19.00638. Epub 2019 Dec 11. PMID: 31826966
Sulpizio AG., Minellia ME., Mao Y*. Glutamylation of ubiquitin ligases by a Legionella pseudokinase (2019) Trends Microbiol. pii: S0966-842X(19)30236-7. doi: 10.1016/j.tim.2019.09.001. [Epub ahead of print] PMID: 31624006
Wan, M., Sulpizio, A.G., Akturk, A., Beck, W.H.J., Lanz, M., Faça, V.M., Smolka, M.B., Vogel, J.P., Mao, Y. Deubiquitination of phosphoribosyl-ubiquitin conjugates by phosphodiesterase-domain–containing Legionella effectors. PNAS. 2019. https://doi.org/10.1073/pnas.1916287116
Sulpizio, A., Minelli, M.E., Wan, M., Burrowes, P.D., Wu, X., Sanford, E.J., Shin, J.H., Williams, B.C., Goldberg, M.L., Smolka, M.B., Mao, Y. Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ. eLife. 2019. eLife 2019;8:e51162
Wasilko DJ, Huang Q, Mao Y*. (2018) Insights into the ubiquitin transfer cascade catalyzed by the Legionella effector SidC. eLife. 17;7. pii: e36154. doi: 10.7554/eLife.36154. PMID: 30015617
Akturk A, Wasilko DJ, Wu X, Liu Y, Zhang Y, Qiu J, Luo ZQ, Reiter KH, Brzovic PS, Klevit RE, Mao Y*. (2018) Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector. Nature. 557(7707):729-733. doi: 10.1038/s41586-018-0147-6. Epub 2018 May 23. PMID: 29795346
Huang Q, Gruner SM, Kim CU, Mao Y, Wu X, Szebenyi DM. Reduction of lattice disorder in protein crystals by high-pressure cryocooling. J Appl Crystallogr. 2016 Feb 1;49(Pt 1):149-157. PMID: 26937238
John David Wasilko, Yuxin Mao. Exploiting the ubiquitin and phosphoinositide pathways by the Legionella pneumophila effector, SidC. Current Genetics. 2016 Feb;61(1):105-8.
Shaogeng Tang, W. Mike Henne, Peter Borbat, Nicholas Buchkovich, Jack Freed, Yuxin Mao, Chris Fromme, Scott D. Emr. (2015) Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments. eLife. 2015 Dec 15;10.7554.
Xi Luo, Jon Wasilko, Yao Liu, Jiayi Sun, Xiaochun Wu, Zhao-Qing Luo, Yuxin Mao. (2015) Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial Phagosome. PLoS Pathog. 2015 Jun 12;11(6):e1004965. doi: 10.1371/journal.ppat.1004965. eCollection 2015.
FoSheng Hsu, Fenghua Hu, Yuxin Mao. (2015) Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling. J Cell Biol. Apr 2014; 209(1)97-110. doi: 10.1083/jcb.201408027
Xiaojian Gong, Xiaofang Chen, Dongmin Yu, Nannan Zhang, Zhongliang Zhu, Liwen Niu, Yuxin Mao, Hunghua Ge. (2014) Crystal structure of Legionella pneumophila dephospho-CoA kinase reveals a non-canonical conformation of P-loop. J Struct Biol. Dec 2014; 188(3):233-39. doi: 10.1016/j.jsb.2014.10.008.
FoSheng Hsu, Yuxin Mao. (2014) The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis. Biochim Biophys Acta. 2014 Sept 24. pii: S1388-1981(14)00193-0. doi: 10.1016/j.bbalip.2014.09.015.
FoSheng Hsu, Xi Luo, Jiazhang Qiu, Yan-Bin Teng, Jianping Jin, Marcus B. Smolka, Zhao-Qing Luo, Yuxin Mao. (2014) The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10538-43. doi: 10.1073/pnas.1402605111. Epub 2014 Jul 8.
Wenhan Zhu, Loubna A. Hammad, FoSheng Hsu, Yuxin Mao, Zhao-Qing Luo. (2013) Induction of caspase 3 activation by multiple Legionella pneumophila Dot/Icm substrates. Cell Microbio. 2013 Nov; 15(11):1783-95
Leila Toulabi, Xiaochun Wu, Yanshu Cheng and Yuxin Mao. (2013) Identification and structural characterization of a Legionella phosphoinositide phosphatase. JBC 2013 Aug 23; 288(34):24518-27
FoSheng Hsu and Yuxin Mao. (2013) The Sac domain-containing phosphoinositide phosphatases: structure, function, and disease. Front Biol (Beijing). 2013 Aug; 8(4):395-407.
Sungkwon Kang, Chae Un Kim, Xiaoling Gu, Roisin M. Owens, Sarah J. van Rijn, Vanissra Boonyaleepun, Yuxin Mao, Timothy A. Springer, Moonsoo M. Jin. (2012) Complex structure of engineered modular domains defining molecular interaction between ICAM-1 and integrin LFA-1. PLoS One. 2012 Aug 30; 7(8)
FoSheng Hsu, Wenhan Zhu, Lucy Brennan, Lily Tao, Zhao-Qing Luo, Yuxin Mao. (2012) Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13567-72. Epub 2012 Aug 7.
Blake-Hodek KA, Williams BC, Zhao Y, Castilho PV, Chen W, Mao Y, Yamamoto TM, Goldberg ML.(2012) Determinants for activation of the atypical AGC kinase Greatwall during M phase entry. Mol Cell Biol. 32(8):1337-53.
Zhong S, Hsu F, Stefan CJ, Wu X, Patel A, Cosgrove MS, Mao Y. (2012) Allosteric activation of the phosphoinositide phosphatase Sac1 by anionic phospholipids. Biochemistry. 51(15):3170-7.
Xue Z, He Y, Ye K, Gu Z, Mao Y., Qi L. (2011) A Conserved Structural Determinant Located at the Interdomain Region of Mammalian Inositol-requiring Enzyme 1{alpha}. J Biol Chem. 286(35):30859-66.
Stefan CJ, Manford AG, Baird D, Yamada-Hanff J, Mao Y, Emr SD. (2011) Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites. Cell. 144(3):389-401.
Zheng Y, Brady OA, Meng PS, Mao Y., Hu F. (2011) C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking. PLoS One. 6(6)
Brady OA, Meng PS, Zheng Y, Mao, Y. and Hu F. (2011) Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1 Journal of Neurochemistry. 116(2):248-59
Manford, A., Xia, T., Saxena, A.K., Stefan, C., Hu, F., Emr, S.D., and Mao, Y. (2010) Crystal structure of the yeast Sca1: implication for its phosphoinositide phosphatase function. EMBO J. 29, 1489-1498.
Mao, Y., Balkin, D.M., Zoncu, R., Erdmann, K.S., Tomasini, L., Hu, F., Jin, M.M., Hodsdon, M.E., and De Camilli, P.(2009) A PH domain within OCRL bridges clathrin mediated membrane trafficking to phosphoinositide metabolism. EMBO J. 28, 1831-1842.
Earlier Publications:
Facchinetti, V., Ouyang, W., Wei, H., Soto, N., Lazorchak, A., Gould, C., Lowry, C., Newton, A.C., Mao, Y., Miao, R.Q., Sessa, W.C., Qin, J., Zhang, P., Su, B., and Jacinto, E. (2008) The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 27, 1932-1943.
Erdmann, K.S.*, Mao, Y.*, McCrea, H.J.*, Zoncu, R., Lee, S., Paradise, S., Modregger, J., Biemesderfer, D., Toomre, D., and De Camilli, P. (2007) A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway. Dev. Cell. 13, 377-390 (*equal contribution).
Mao, Y., Senic-Matuglia, F., Di Fiore, P.P., Polo, S., Hodsdon, M.E., and De Camilli, P. (2005) Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain. Proc. Natl. Acad. Sci. USA 102, 12700-12705.
Mao, Y.*, Vyas, N.K.*, Vyas, M.N., Chen, D.H., Ludtke, S.J., Chiu, W., and Quiocho, F.A. (2004) Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer. EMBO J. 23, 2963-2971.
Takashima, H., Boerkoel, C.F., John, J., Saifi, G.M., Salih, M.A., Armstrong, D., Mao, Y., Quiocho, F.A., Roa, B.B., Nakagawa, M., Stockton, D.W., and Lupski, J.R. (2002) Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy. Nat. Genet. 32, 267-272.
Lohi, O., Poussu, A., Mao, Y., Quiocho, F., and Lehto, V.P. (2002) VHS domain – a longshoreman of vesicle lines. FEBS Lett. 513, 19-23.[Full Text]
Mao, Y., Chen, J., Zhang, B., Maynard, J.A., and Quiocho, F.A. (2001) A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis. Cell 104, 433-440.
Mao, Y., Nickitenko, A., Duan, X., Lloyd, T.E., Wu, M.N., Bellen, H., and Quiocho, F.A. (2000) Crystal Structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. Cell 100, 447-456.
Ye, J., Mao, Y., Gui, L., Chang, W., and Liang, D. (1999) Crystal structure studies of destripeptide (B28-B30) insulin. Science in China, Ser. B 43, 178-186.
Mao, Y., Li, M., Wan, Z., Jiang, T., An, X., Liang, D., Liu, F., Huang, C., Chen, L., and Hu, M. (1999) Preparation of destripeptide (B28-B30) insulin and destetrapeptide (B27-B30) insulin and preliminary X-ray crystallographic study of destripeptide insulin. Progress in Natural Sciences. 9, 241-247.